The Center for Genomics and Bioinformatics Research
 
 
                       
          The Center for Genomics and Bioinformatics Research was established in December 2004 by a group of Molecular biologists at the Prince of Songkla University, one of the most prestigious universities in Southern Thailand. With rapid changes in biological research, information technology has become necessary. We realize the need for university infrastructure and personnel with skills in mathematics and computing as well as in the biological sciences. Our group is well equipped with comprehensive wet-lab facilities in molecular biology and genomics, and will develop necessary computational infrastruture to support research and teaching in bioinformatics and computational biology.
          Our group is seeking budget and partnerships for the execution of its bioinformatics technology initiatives, including human resources development, and investment in research facilities and infrastruture.

   

   Shrimp Immune and Oil Palm
Professor Dr.Amornrat Phongdara
Director, Lecturer and Researcher
E-mail:: amornrat.p@psu.ac.th, pamornra@yahoo.com

Research of Interest: ::

1. Shrimp Immune (Project leader)
      The crustacean immune response can be divided into cellular and humoral components. The cellular component comprises phagocytosis and cellular encapsulation of potential pathogens by haemocytes. The humoral component is characterized by temporarily enhanced antimicrobial activity in the cell-free hemolymph. Unlike vertebrates, invertebrate responses, whether local or systemic, do not utilize a clonal amplification of the cells producing given effector molecules and lack specific immunoglobulins and immunological long-term memory (Niere et al., 1999). However, all the mechanisms conserved between invertebrates and vertebrates are related to innate immunity (Pasquier, 2001). Knowledge of shrimp immunity at the molecular level has been increasing rapidly in recent years, and several genes involved in anti-microbial have been cloned and characterized. EST upon viral infection has been studied and sequences have been reported (Tassanakajon et al., 2006).
      Our works are concentrated on the recovery of immune genes isolated from shrimp cDNA library. One of the clones, showed a statistically significant similarity with the gene encoding Fortilin, also known as TCTP. Crustacean Fortilin isolated from Penaeus monodon, is well conserved and has a Ca 2+ binding domain. Pm–Fortilin has anti-apoptotic properties and is present at high levels during the onset of viral infections in P. monodon. The possibility of using rFortilin to protect against White Spot Syndrome Virus (WSSV) infection was investigated. The result implies that injection of recombinant rFortilin decreases viral infection by an unknown mechanism, but probably by inhibiting viral replication (Tonganunt et al., 2009).

2. Oil palm
     Oil palm (Elaeis guineensis Jacq.) is a monocotyledonous perennial plant with the highest yielding oil-producing crop in the world. Oil can be extracted from both the mesocarp and kernel. Palm oil has multiple uses, such as the production of cooking oils, margarines, soaps, detergents, and fuel. To increase oil palm yield to meet the ever-increasing global demands, genetic improvement of oil yield and quality is desirable. Conventional breeding of oil palm is a time-consuming, low efficiency process due to the trees long reproductive cycle and slow seed maturation (Mayes et al. 2000). Modern biotechnology approaches such as the use of tissue culture, genetic transformation and marker-aided selection may prove to be a better way to further improve the commercial value and productivity of oil palm (de Touchet et al. 1991; Chowdhury et al. 1997; Mayes et al. 2000).
     Our group is working on the genes discovery from Oil palm (Elaeis guineensis Jacq.) and develops a suitable method for gene transformation into oil palm callus.


Dr. Warapond Wanna
Lecturer and Researcher
E-mail:: w.wanna@yahoo.com

Research of Interest: ::
Dr.Moltira Tonganunt
Lecturer and Researcher
E-mail:: Tonganunt@yahoo.com

Research of Interest: ::
Study the biological function of Pm-RACK1 (Receptor for activated protein kinase C1). Pm-RACK1 has been identified as a specific cellular target protein for VP9, a nonstructural protein of white spot syndrome virus (WSSV). The interaction of these two proteins may be involved in mediating intracellular functions of VP9.

Ms. Alisa Nugkaew
Researcher
E-mail:: joy_alisa@yahoo.com

Research of Interest: ::
Previous research has developed molecular markers for high yield selection in oil palm (Elaeis quineensis facq.). Our next direction is to use the expressed sequence tag (EST) library of oil palm to understand regulation of growth, development and defensive response in the palm. I am especially interested in regulation of genes responsible for lipid synthesis in the oil palm.

Ms. Kantamaht Kanchanapoom
Scientist
E-mail:: kantamaht.k@psu.ac.th

Research of Interest: ::
  Ovarian Maturation in shrimp
Associate Professor Dr.Wilaiwan Chotigeat
Deputy Director, Lecturer and Researcher
E-mail:: wilaiwan58@hotmail.com,wiliwan.c@psu.ac.th

Research of Interest: ::

1. Mechanism of ovarian maturation in shrimp
    The molecular processes involved in ovarian development and oocyte maturation of panaeid shrimp, especially P. merguiensis are not fully understood and there is little published information on the regulation and bio-molecules involved in ovarian development of the broodstock. Therefore, the molecular mechanisms of ovarian muturation in shrimp, such as expression of genes involved in ovarian development are investigated. Proteins involved in ovarian muturation are identified. In addition, stimulants and mechanisms of ovarian maturation are screened and studied.

2. Molecular biology of immunne response in shrimp
    White Spot Syndrome Virus (WSSV) infection is now found in most shrimp farming areas of the world and is causing significant economic losses for the shrimp farming industry. Prevention to control the disease such as vaccinating against the virus would be highly desirable. Immunno-stimulants are investigated in our laboratory such as fucoidan, phagocytic activating protein, white spot syndrome binding protein, DNA vaccines and etc.

3. Molecular biology of rubber tree
    ESTs library of latex was performed and high expression genes in latex were found so genes involved in rubber biosynthesis and immune response will be further studied.

 Dr.Decha Sermwittayawong
Lecturer and Researcher
E-mail:: decha.s@psu.ac.th

Research of Interest: ::
Biomedical Research

Ms.Passanee Deachamag
Researcher
E-mail:: deachamag@hotmail.com

Research of Interest: ::
Study the stimulation of shrimp's immune system that protects shrimp from White Spot Syndrome Virus (WSSV) by phagocytosis activating protein (PAP) and neutralization of WSSV by White Spot Syndrome Virus binding protein (WBP).
   Bioinformatics
Mr. Pitipon Meemak
Lecturer and Researcher
E-mail:: s4522040@yahoo.com

Research of Interest: ::
MicroRNAs play important roles in biological processes in a wide variety of organisms from plants, viruses, and animals. My research focus is to develop the workflows for microRNAs analysis in expressed sequence tags (ESTs) of shrimp.

Ms.Unitsa Sangket
Lecturer and Researcher
E-mail:: usangket@yahoo.com

Research of Interest: ::
Develop a more effective program to find common causal variants in Genome that may cause disease.
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       :: Contact ::                                         Center for Genomics and Bioinformatics.
                                                                            Faculty of Science, Prince of Songkla University,
                                                                            Kanchanawanish Rd., Hat-Yai, Songkhla, Thailand, 90112.
                                                                           Tel: +66-7428-8117    E-mail: gnome.psu@gmail.com

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